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Combining with Vitamin C injections may enhance skin-lightening effects (doctors guidance required)

Inducers of CYP3A4 The concomitant use of Hydrocodone Bitartrate and Acetaminophen Tablets and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of hydrocodone [see CLINICAL PHARMACOLOGY], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to hydrocodone [see WARNINGS]

Research doses in studies range from 600 mg to 1,200 mg twice daily, but this remains investigational and should only be used under medical supervision

Frontiers in Neuroscience, 14, 1062