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In studies of duloxetine in smoking and nonsmoking psychiatric patients (not directly related to pain relief), serum levels of the drug were lower in smokers than in nonsmokers, suggesting that tobacco smoke components induce drug-metabolizing enzymes (e.g., cytochrome P450 1A2) [108, 109]

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These early reports show our settlement provisions are working, resulting in the detection and destruction of thousands of smuggled cigarettes. Contraband cigarettes can cost states hundreds of thousands of dollars in lost tax revenue, and hinder smoking cessation efforts, Tong said