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HUBERMAN: I tend to do that in the winter months because, of course, you don't just need hydration on hot days and in the summer and spring months, but also in the winter when the temperatures are cold and the environment tends to be dry

Where guidelines lacked clarity, primary literature was used to fill critical gaps

10.1111/j.1600-0854.2010.01149.x 153 VitoloO

Recent reviews indicate that suitably engineered CQDs can traverse the BBB via receptor-mediated endocytosis and adsorptive-mediated transcytosis, with surface charge and amphiphilicity influencing endothelial interactions and uptake efficiency, although the relative contributions of these pathways are not yet well defined [143]