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Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis ( 3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Skjevling et al., 2024)

10.1016/j.biochi.2018.12.002 59 RathS.HeidrichB.PieperD

The Amyloid Cascade Hypothesis: Are We Poised for Success or Failure? Journal of Neurochemistry 139: 237252

doi: 10.1016/j.brainresbull.2018.11.013