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In summary, encapsulating a oleophilic prodrug of Dex into PLGA-PEG NPs presents to be a prospective strategy for improving pharmacological profiles and reducing joint inflammation in mouse models of RA

Dabei scheint es keine Rolle zu spielen, ob die Beschwerden systemisch oder traumatisch bedingt sind: Das Peptid wirkt bei rheumatischer Arthritis genauso gut wie bei Meniskusrissen, Tendinosen, Bnderrissen und Verstauchungen

D-Nle-Cys-Ile-NH-(CH2) 5-CONH2 inhibits B16-F10 murine melanoma cell migration and lung colony formation To evaluate the prospective utility of the 6-AH family members' as potential therapeutics, we examined the capacity of [D-Nle-Cys-Ile-NH-(CH 2 )5~CONH2], an analog that exhibits a strong inhibitory profile against HGF-dependent Met activation, to suppress the migratory and lung colony-forming capacity of B16-F10 murine melanoma cells