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Recent studies have revealed the elevation of SIRT1 in a rat model of status epilepticus, a common neurological emergency which is defined as a prolonged seizure with at least five minutes or multiple seizures with incomplete recovery of consciousness [117] and its neuroprotection is conducted via deacetylation of proliferator-activated receptors and coactivator 1 (PGC-1), an important regulator for mitochondrial biogenesis [118, 119]

Phase 1-2 trial of the BRAF inhibitor dabrafenib (D) plus MEK inhibitor trametinib (T) in BRAF V600 mutant colorectal cancer (CRC): Updated efficacy and biomarker analysis 32(5s), 2014

Glutathione is often called the master antioxidant because of its essential role in protecting cells from oxidative stress and supporting overall wellness

The implication of CHAC1 in increasing sensitivity to ferroptosis was recently confirmed in Burkitt's lymphoma during artesunate-induced ferroptosis (61)