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Although in vitro studies with artificial substrates failed to show an impact of the expansion of the polyQ segment of ATXN3 on its DUB activity [37, 73, 74], the insolubility and immobile nature of the inclusions in vivo [75] may make mutant ATXN3 less prompt to locate at the sites at which editing of Ub chains is needed

By neutralizing oxidative stress, glutathione protects the skin at the cellular level, preventing oxidative damage that causes fine lines, sagging, and dullness

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