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Another enzyme used to reduce terminus multiplicity is T4 polynucleotide kinase (PNK), which catalyzes the phosphorylation of 5-OH termini to generate 5-P and removal of phosphoryl groups from 3-P and 2,3-cyclic phosphate (3-cP) termini to generate 3-OH 20,21

Previous research highlights that younger populations and existing tobacco smokers are more likely to use these products, with dual use of conventional cigarettes reported by more than two-thirds of HTP users 6

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Our customers value the product design and quality, but also our localized customer service and the 12-month warranty. On the back of these thoroughly positive developments, jouz hopes to enter further markets in the medium to long term