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In an open-label phase II trial, curcumin treatment (8 g/day) in combination with the anticancer drug gemcitabine was associated with severe abdominal pain in 7 out of 17 patients with advanced pancreatic cancer, leading to the treatment being discontinued in five patients while curcumin dosage was reduced to 4 g/day in two patients (79)

Ferulic acid (from Angelica sinensis and Ligusticum chuanxiong) and astragaloside IV (from Astragalus) have similarly demonstrated reduction in cardiac fibrosis and improved post-MI ventricular function, linked to modulation of inflammatory cytokines and collagen synthesis (Lu et al., 2015

Long-term Neuroprotection: Helps protect against neurodegenerative conditions by maintaining neuron health and function, thereby prolonging cognitive longevity

Flagg, J.C