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In tumor cells, where intracellular GSH levels are often elevated, this reductive environment may facilitate metal-catalyzed redox cycling and paradoxically intensify oxidative stress

The therapy pairing neratinib with RSL3 enhances lipid peroxidation and mitochondrial impairment, resulting in increased ferroptotic cell death, providing a promising strategy for improving outcomes in patients with HER-2-positive breast cancer who may not adequately respond to standard treatments (Hu et al., 2024

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S11K), which tended to increase, and isobutyrate (Fig