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Vitamin B-12 is an important vitamin that you usually get from your food

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However, despite the widespread nature of this condition, there are no internationally standardised guidelines regarding dosage regimes, optimal formulation, frequency of administration of B12 therapy and monitoring of therapeutic effect, leading to significantly variable international practice ( In this review, we aim to summarise the complex pathway by which B12 is absorbed and metabolised and subsequently describe the inherited and acquired causes of B12 deficiency