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In high-fat diet (HFD) mouse models, subcutaneous dosing at approximately 0.3, 3, and 30 nmol/kg/day over 21 days produced dose-dependent body weight reductions

The decreased macrophages (clusters 2, 4, 5, 7) suggested that FAPCAR-T cells disrupted the viscous inflammatory-fibrosis cycle via the clearance of overactivated fibroblasts, which was consistent with the flow cytometry and proteomics results