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Along with connective tissue proteins, many proteins contain cysteine-rich epidermal growth factor-like domains that may be preferential sites of homocysteinylation (Krumdieck and Prince, 2000)

As a reversible PTM, glutathionylation is emerging as a key redox-based signaling mechanism that helps cells respond to environmental stress by regulating specific signaling cascades

31 Using a conventional double knockout mouse model for the Gstp1 and p2 genes, we show that GSTP1/P2 is required for the activation of signaling pathways involved in liver regeneration

Once their buffering capacity is exceeded, sustained elevation of subplasmalemmal Ca 2+ favors prolonged SOCE activation and a self-reinforcing injury loop (17)