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Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

Discussion 1) The goal of the research team of McCoy et al was to find an AngIV analog capable of permeating the blood brain barrier and eliciting procognitive activity by improving the metabolic stability of the tri- and tetrapeptide N-terminals of AngIV analogs

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