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As the field matured, concern emerged that ovarian epimerase overactivity in PCOS shifts local MI to DCI, creating an ovarian paradox

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Results showed that carnitine significantly improved sperm motility and shape, though it didnt have a measurable effect on sperm count or increase pregnancy rates

For instance, overexpression of AR, such as that caused by AR gene amplification or enhancer repetition, increases the number of AR binding sites [60] and genome-wide chromatin relaxation [61]