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[DOI] [PMC free article] [PubMed] [Google Scholar] [73].Chen C, Wang D, Yu Y, et al

Women with POF present with amenorrhea, hypergonadotropinism, and hypoestrogenism (173)

[1] Other causes can include infections such as Mycoplasma pneumoniae and cytomegalovirus, or the cause may remain unknown

in addiction a decrease in apolipoproteins degradation due to liver function alteration has been hypothesized in the subgroup with high estradiol levels (94)