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demonstrated that Foxp3, the master transcription factor of Tregs, reprograms their metabolism to thrive in low-glucose, high-lactate environments

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Both free Rifs solution and Rif-SLNs exhibited MIC values of 8 g/mL and 4 g/mL, respectively, suggesting the superior effectiveness of Rif-SLNs compared to free rifampicin

These parameters may be evaluated using tumor biopsy specimens and patient-derived samples through a combination of complementary experimental and clinical methodologies, including immunohistochemistry or spatial proteomics to assess FSP1 expression and localization, metabolomics or lipidomics-based omics approaches to quantify CoQ redox state and lipid peroxidation signatures and functional ferroptosis-sensitivity assays in patient-derived tumor models such as organoids or xenografts