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Several guidelines and well-conducted studies exist to guide the clinical use of pharmacotherapy for tobacco smoking cessation

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Similarly, the long-term exposure (up to 12 weeks) of human bronchial epithelial BEAS-2B cells can be employed to show that the functional and molecular changes linked to lung carcinogenesis are less pronounced following cMRTP aerosol than cigarette smoke exposure [80]

Packages must clearly display the nicotine dose and health warnings, and must have child-resistant closures to ensure greater consumer safety.