It is worth noting that studies reported that hypoxiadriven stabilization of HIF1 enhances Gln metabolism by upregulating glutaminase expression and Gln transporter activity, thereby supporting redox homeostasis and cell survival under lowoxygen stress
Ajani JA, Xiao L, Roth JA, Hofstetter WL, Walsh G, Komaki R, Liao Z, Rice DC, Vaporciyan AA, Maru DM, Lee JH, Bhutani MS, Eid A, Yao JC, Phan AP, Halpin A, Suzuki A, Taketa T, Thall PF, Swisher SG
Understanding the structural characteristics, release mechanisms, and clinical application differences of these two types of linkers is of great significance for optimizing ADC design, improving efficacy, and ensuring safety
Synthetic analogs of luteinizing hormone releasing hormone (LH-RH) substituted in position 6 and 10