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The convergence of synaptic dysfunction, mitochondrial failure, neuroinflammation, and impaired protein clearance underscores the complexity of the disease and the need for early, multi-mechanistic neuroprotective interventions

Researchers who skip titration steps or escalate doses too quickly experience dramatically worse GI symptoms

In mouse and rat models of choline and methionine-deficient diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD), females are reported to be more protected than their male counterparts 88