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Clinical signs are indistinct and include lethargy, depression, ataxia, anorexia and intermittent vomiting, and in severe cases, can induce neurological disease and blindness in cats

(1) Studies on the Validation of In Vivo Obesity Intervention Effects A large number of in vivo animal experiments have confirmed that it exerts significant weightloss and fatreducing effects with favorable safety profiles.In a mouse model of highfat dietinduced obesity, administration of 20 mg/kg NNMTi daily for 11 days resulted in a significant reduction in body weight

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Exclusion criteria were: (a) in-vitro RCTs