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While they can derive from endothelial cells, bone-marrow cells, and epithelial cells [18], single-cell mapping studies suggest that pericytes and resident fibroblasts are the main source [19]

Side effect profiles: injection site reactions vs GI symptoms Subcutaneous injection side effects: The most common is injection site reactions

Together, they create a more powerful metabolic effect than either receptor alone, which explains why tirzepatide outperforms semaglutide in clinical comparisons