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Furthermore, understanding the underlying causes of constipation, such as dietary fiber intake or stress levels, can empower individuals to make informed lifestyle changes that support long-term digestive health

14 Other major medical organizations do not have any recommendations for screening low-risk patients

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Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems