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The activated Akt can in turn phosphorylate various target proteins involved in survival and differentiation pathways, including BCL2 associated agonist of cell death (Bad), GSk3, nuclear factor-B (NF-B), FoxO1, FoxO3a, and FoxO4 [88]

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Prog Mol Biol Transl Sci (2009) 88:5784

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Ibrutinib treatment reduces PMN-MDSC levels in chronic lymphocytic leukemia (CLL) within three months, while leaving M-MDSC unchanged (106)

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