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Activation of S1PR2 by specific BAs, particularly conjugated BAs such as taurocholic acid (TCA), stimulates the RhoA/ROCK1 signaling axis in macrophages, facilitating M1 polarization and NLRP3 inflammasome activation

It protects cells from free radicals and then sticks to harmful toxins

However, targeting specific gut microbiota with antifungals often yields unsatisfactory results, as some drugs are rapidly metabolized and fail to reach the lower digestive tract 167

An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly