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If the DNA damage is too severe or there is a defect in the DNA repair pathway, DNA repair will ultimately fail 5-7

For instance, someone with Crohns disease might need: Higher initial doses to overcome malabsorption More frequent injections during the maintenance phase Regular checks on B12 levels to adjust dosages as needed Dosage Modifications for Elderly Patients Elderly patients have special needs when it comes to vitamin B12 injection dosages

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The areas attracting the most focused attention include inflammatory bowel disease, where the preclinical evidence base is deepest