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Animal studies have reported outcomes including reduced adiposity, improved insulin sensitivity, and altered lipid profiles, all without changes in food intake

This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

It is superimposed on the fractions of each Niclosamide species (Nic OH and Nic -ve ) (left axis) from the Henderson Hasselbalch analysis (from Figure S3 )