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Mechanistically, GPR146 promotes adipogenesis in preadipocytes via Gq-PKC-AKT signaling, increasing lipid storage capacity, and enhances lipolysis in mature adipocytes through ERK activation, elevating circulating FFA

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The review emphasized that carriers designed using ionizable polymers, such as alginate and gelatin, can remain stable in the acidic gastric environment and release their payload in alkaline conditions- an effective strategy for enhancing drug bioavailability (67)

PMOS-related insulin resistance causes hyperinsulinaemia chronically elevated insulin that overstimulates androgen production in the ovaries