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In silica-induced fibrosis models, blocking glycolysis or HIF-1 signaling reduces intracellular glycine levels, which correlates with decreased collagen deposition and attenuated fibrotic responses [110]

These individuals may experience abrupt elevations in alanine aminotransferase (ALT) levels exceeding 1,000 U/L within 14 months of use, often accompanied by autoimmune hepatitis-like features

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Analysis of protein adduction kinetics by quantitative mass spectrometry: competing adduction reactions of glutathione-S-transferase P1-1 with electrophiles