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Pathways related to immunoglobulin, production, defense responses and B cell activation were among those downregulated, including immunoglobulin production ( IGKV112 , IGKV117 ), adaptive immune response (for example, CX3CR1 , FCGR1BP ) and B cell activation ( HDAC9 , CD180 , MNDA ) (Extended Data Fig

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Endocrinology 162:bqab091 Gorini F, Vassalle C (2022) Selenium and selenoproteins at the intersection of type 2 diabetes and thyroid pathophysiology

Further physical examination revealed diffuse maculopapular erythema on almost the whole body (more than 30%), some erosion, and denuded skin on the chest and lower extremities