202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione
Chng Lo Ha v Ci Thin Sinh L: Vin ung ny gip chng lo ha, ci thin kh nng sinh l v mang li sc sng cho c th, gip bn lun t tin v khe mnh
Specifically, it upregulates specific microRNAs (miRNAs) to silence the expression of two critical molecules: miR-155, miR-181b, and miR-361 target Aicda, whereas miR-23b, miR-30a, and miR-125b target Prdm1 (encoding B lymphocyte-induced maturation protein-1, Blimp-1)
Radoslav Bozic at the University of Zagreb, Croatia