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Retrieved March 3, 2011
While this could correspond to the known pharmacokinetics of CBD, including its half-life and T max ( Importantly, CBD pharmacology and placebo mechanisms may converge at the neurobiological level
To be sure, CBDs hepatotoxicity potential is largely unproven, with liver injury being possible primarily with very high doses, but the risk of adverse events increases when CBD is combined with certain medications.45 CBD is metabolized by cytochrome P450 (CYP) liver enzymes , the same ones that metabolize almost half of all prescription drugs, including but not limited to:18 Anticonvulsants Immunosuppressants Protease inhibitors Anti-infectives Statins Antidepressants Blood thinners Oral contraceptives Antipsychotics At the very least, combining CBD with any such medication may result in therapeutic failure of the medication
The whole natural, additive-free fight has been a thorn in the side of tobacco control advocates for years
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