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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

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Evidence from animal models shows that daily subcutaneous injections of PTH 134 significantly increased the bone mineral content and density as well as the total osseous tissue volume, torsional strength and stiffness [27, 30]

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