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Shikonin blocks CAF-Induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1

Documented Peptide Experience Request reference formulations or batch records of their previously mass-produced copper peptide products

The PLS-DA and heat map in Figure 1 show that resistant cells treated continuously with 1 M tamoxifen (4+1), a concentration that is often measured in patients (24), showed different metabolic clusters compared to the other two resistant groups (50 and 35x6) and the control (tamoxifen-sensitive) group, indicating that they had markedly different metabolic characteristics ( Figure 1A )

It needs glutathione as a co-substrate [23]