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Drosophila and mice with the Y314S variant both showed degeneration of dopaminergic neurons and locomotor defects (Lin et al., 2020), providing direct evidence for the involvement of cIII in PD pathogenesis

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Effects of NNMT inhibitors on lipogenesis and intracellular levels of metabolites, including NNMT reaction product 1-methylnicotianamide (1-MNA) were evaluated in cultured adipocytes