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This review synthesizes evidence from peer-reviewed studies published between 2020 and 2026, focusing on mechanisms, efficacy, and safety

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While large-scale human trials are still developing, a small pilot study with 16 patients experiencing knee pain showed promising pain relief with no adverse effects

Strengths and limitations This systematic review has several strengths in its methodology that enable us to assess the existence of disease biomarkers and the biological processes most likely to be affected by epigenetic deregulation