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Keywords : head and neck cancer, polyphenol, oxidative stress, cancer metabolism, reactive oxygen species (ROS), clinical biochemistry, translational medicine, polyphenol therapeutic potential, clinical studies Head and neck cancer (HNC) accounted for more than 66,920 new cases in 2023 (49,190 men and 17,730 women), causing more than estimated 15,400 deaths (11,210 men and 4,190 women), accounts this disease for about 4% of all cancers in the United States alone [1]

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Ionizing radiation leads to genetic instability, ultimately resulting in cancer cell apoptosis

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