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LSECs and hepatocyte injury then lead to activation of the coagulation cascade and thrombocytopenia

An additional MAPK system involving MEKK1-MKK2-MPK4/6 works downstream to ROS and helps in biotic and abiotic stress signalling networks [114,115,116]

The polyethylene glycol (PEG) and polyoxyethylene (100) stearate (PEG-100 stearate) matrix gradually softened, dissolved, and released EGCG-Zn at body temperature, facilitating the maintenance of effective drug concentrations in the rectum [47,48,49,50,51]

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