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sometimes mild right upper quadrant discomfort, hepatomegaly, acanthosis nigricans, or cryptogenic cirrhosis Often associated with features of metabolic syndrome: type 2 diabetes, obesity, dyslipidemia (hypertriglyceridemia, low HDL cholesterol, hypobetalipoproteinemia), and cardiovascular disease Increased AST and ALT levels (usually 2.0 Acute decompensated Wilson disease Anhepatic Primary nonfunction of allograft within 7 d of transplant Hepatic artery thrombosis within 7 d of transplant Cirrhosis from any cause MELD-Na score, calculated MELD-Na score exceptions Hepatocellular carcinoma Perihilar cholangiocarcinoma Hepatopulmonary syndrome Portopulmonary hypertension Primary hyperoxaluria Familial amyloid polyneuropathy Cystic fibrosis Metabolic disease (urea cycle disorder or organic acidemia) Hepatic artery thrombosis (within 14 d of transplant but does not meet criteria for status 1A) Appeal to regional review boarda Abbreviations: ICU, intensive care unit

This interruption may lead to the accumulation of senescent cells - those that have stopped dividing but do not die, contributing to cell aging