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In most cases, these symptoms resolve within a few days as the gut microbiome adjusts to the new supplement

Unusual tiredness or lack of energy Recurring neurological symptoms Inadequate improvement in overall well-being If you notice these signs, talk to your healthcare provider

These are reproducible animal findings

From the previous section, it follows that inherited disorders leading to dramatic elevations of homocysteine in the blood and urine derive from genetic defects in homocysteine transsulfuration or re-methylation, or in the transporters and enzymes involved in the delivery and metabolism of the key cofactors required for these metabolic pathways (specifically folate and vitamin B12)