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The mice were injected intravenously with PBS, Ru(II)-OH, NP2, NP4 (2 mg/kg Ru) on days 1, 4, 7, 10, respectively

RT-qPCR analysis demonstrated that the TFR2 mRNA levels were downregulated in healthy and ER-positive breast cancer cells and upregulated in ER-negative breast cancer cell lines, particularly in TNBC cell lines (Fig

Funding This research was supported by the China Postdoctoral Science Foundation (2021M701420), Guangdong Basic and Applied Basic Research Foundation (2022A1515110021), Guangzhou Science and Technology Projects Foundation (202201020002), Scientific Research Project of Guangdong TCM Bureau (20221105), Guangdong Medical Research Foundation (A2022214)