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Once you find the dose that is not creating these problems, over time your body may adjust to it and you won't have such a strong reaction

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2.2.1 Oxidative stress and mitochondrial dysfunction METH significantly increases the production of ROS and reactive nitrogen species, overwhelming antioxidant defenses in neurons

If the individual has significant accumulation (older age, chronic disease, prior chemotherapy), the first course may produce the most noticeable effects Subsequent courses: Target newly accumulated senescent cells