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C domains are most commonly encoded in the same coding DNA sequence (CDS) as their acceptor molecules, upstream of the corresponding A domain and there are only very few examples were a C domain is located in the C terminal proximitiy of the preceding CDS in NRPS 32,33,34
Coming off the peptides doesn't reverse the repair that occurred
For example: Growth hormone-releasing peptides (GHRPs) stimulate pituitary cells specifically to secrete growth hormone Neuropeptides like Semax modulate brain-derived neurotrophic factor (BDNF) expression in neurons Body protective compounds like BPC-157 interact with growth hormone receptors in the gastric mucosa The specificity-potency combination is what distinguishes bioactive peptides from broader pharmacological agents
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