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It is expected that OX/ROS in aerosols of ENDS/e-cigs will have an impact on cellular oxidative stress, redox imbalance, and lung inflammation, but this is still not clear in vitro in lung cells and in vivo in lungs

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7D) were observed with latitude (r = 0.259), longitude (r = 0.311), and sampling year (r = 0.205), suggesting that protected areas located further north and further east tended to show higher contamination, while those sampled in more recent years tended to show lower cigarette butt burdens