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Probiotic use before and throughout the eradication treatment, especially when lasting more than 2 weeks, showed superior outcomes, with the best results observed when probiotics were combined with bismuth quadruple therapy (Shi et al., 2019)

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Conversely, direct knockdown of PGAM5 results in increases in the mtDNA copy number and transcript levels at the cellular level, the normalization of mitochondrial respiration, inhibition of mitochondrial ROS production, and prevention of aberrant activation of the mPTP 53