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Weakening of the endogenous antioxidant system leads to uncontrolled ROS production that outweighs the antioxidant capacity of the brain, causing developmental neurotoxicity

Overexpression of BnPCS1 lines showed better growth and biomass yield, along with exhibiting higher Cd accumulation and translocation compared to WT, which led to Cd stress tolerance [47]

BH4 is an essential cofactor and plays multiple roles in the regulation of oxidative stress and inflammation ( DHODH, within the mitochondria, is an enzyme that generates ubiquinol by catalyzing the conversion of the molecule dihydroorotate (DHO) to orotate (OA)