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Because it is unlikely that humankind will give up drugs, nicotine included, he writes, the findings from the studies presented in this issue suggest that ENDS, and JUUL in particular, can be an acceptable substitute for more harmful cigarette alternatives. (It is duly noted that Fagerstrm has served as a paid consultant to Philip Morris International and British American Tobacco.) Outside the world of corporate-sponsored research, the existing scientific literature is mixed, at best, on the question of whether products like Juul offer effective means of smoking cessation