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doi: 10.1155/2016/6235641 86 NakamuraHTakadaK

Safety evaluation of a 28-day high-dose (40 mg/d) spermidine supplement in healthy elderly men revealed good safety and tolerability (NCT05459961)

doi: 10.1073/pnas.1515386112

That figure came from an assay-specific in-vitro spine-density assay (picomolar Dihexa versus nanomolar BDNF) and does not mean Dihexa is millions of times more effective in a living brain