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It is regularly employed as a primary precursor to S-adenosylmethionine (SAMe) in laboratory studies analyzing cellular transmethylation reactions

stomach pain increased salivation quick heavy breathing tachycardia 1) hypertension headache pale skin muscle fasciculations & weakness seizures Late inhibitory phase (including Muscle paralysis & Ganglionic blockade) (30 mins to an hour): bradycardia diarrhea dyspnea shallow breathing hypotension lethargy / coma severe muscle weakness & paralysis respiratory failure (paralysis of diaphragm) Pharmacokinetics: Nicotine is well absorbed through the skin Major drug Interactions: May alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline