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Mechanism of Action Enzymatic Protection Mechanism : The phenylacetyl group acts as a decoy substrate for glutathione-degrading enzymes, redirecting their activity away from glutathione itself and toward cleaving the protective phenylacetyl modification

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Consistent with this observation, K-Ras sensitizes cells to glutamine deprivation, and K-Ras knockdown rescues cells from apoptosis induced by low glutamine levels 187